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DBL%20Hendrix%20small.png College chemistry, 1983

Derek Lowe The 2002 Model

Dbl%20new%20portrait%20B%26W.png After 10 years of blogging. . .

Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. He's worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis and other diseases. To contact Derek email him directly: derekb.lowe@gmail.com Twitter: Dereklowe

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In the Pipeline: Don't miss Derek Lowe's excellent commentary on drug discovery and the pharma industry in general at In the Pipeline

In the Pipeline

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April 3, 2005

Don't Talk To Yourself So Much

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Posted by Derek

I've been re-reading Francis Crick's memoir What Mad Pursuit, and this passage struck me:

". . .it is important not to believe too strongly in one's own arguments. This particularly applies to negative arguments, arguments that suggest that a particular approach should certainly not be tried since it is bound to fail. . .While one should certainly try to think which lines are worth pursuing and which are not, it is wise to be very cautious about one's own arguments, especially when the subject is an important one, since then the cost of missing a useful approach is high. . .

Be sensible but don't be too impressed by negative arguments. If at all possible, try it and see what turns up. Theorists almost always dislike this sort of approach."

Right on target. In my field, there is hardly an experiment worth doing that can't be objected to right at the start. Counterexamples abound, theoretical reasons why things won't work out are everywhere. Too sterically hindered, not nucleophilic enough, an interfering functional group somewhere else in the molecule, wrong solvent, wrong catalyst, wrong temperature, wrong everything. If you listen to every one of these objections, even when they're coming from inside your head, you'll never do anything at all. True, you'll never be wrong, but only at the cost of never being right.

This is on my mind tonight, because I'm getting close to a revival of a series of experiments that I've been messing around with for nearly three years now. It's a very interesting idea whose details, painfully, I'm not at liberty to lay out. Not yet. I'm reposting my writings on this work over in the Birth of an Idea category at the right, in case you're interested in seeing what scientific excitement does to a person.

The whole time, I've hardly had the tiniest bit of experimental success, it pains me to say. But I'm back with another variation. Every time I'm more sure that things are going to work. Perhaps, after two years of being quite wrong, I might make the switch to quite right. . .

Comments (2) + TrackBacks (0) | Category: Birth of an Idea | Who Discovers and Why


COMMENTS

1. Eric Garland on April 4, 2005 3:38 PM writes...

Derek, this post is inspiring for a number of reasons. For those of us searching for success in the world, it is so easy to believe that rewards come in a rational, linear fashion. That if only we followed the right steps, that if we tiptoe carefully enough, we won't have to ever be wrong.

Maybe this is completely unrelated, but I just watched the DVD documentary of the making of Star Wars. For a masterpiece, it was an insane project from the start. Everything that could go wrong, did, and most of Hollywood thought it was doomed and ill-advised from the start. To any rational person, it should have crashed and burned. And yet a non-linear vision drove Lucas toward the final, breathtaking product.

Maybe I'll go back and start fooling around with some more impossible projects.

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2. Lyndon Lawrence on April 5, 2005 10:29 AM writes...

I hear ya!

I'm not sure if you have heard of a psychiatrist called Viktor Frankl, so I will assume not.

He had, IMHO, some very interesting thoughts on why people continue to mull over the "maybe if" scenarios and ended up spending a lot of time 'deciding' on whether or not to do something - I might say that people can become procrastinating Ents - and that's something to be avoided.

As 'the course of true love never ran smooth' - perhaps it is such with the other aspects of our being and doing. Whilst their is a social force for us all to perform, it does not often take notice that most change is precipitated by foundation work, carried out by others in time gone by. Therefore, some breakthroughs are being made now, which will only realised later, perhaps after we are done and dusted.

My feeling is - do what your conscience guides you towards - ignore the internal chatter when it serves no positive purpose and as Sir Ranulph Fiennes says; "Less thinking - More doing!"

Thanks for this post.

Lyndon

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