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Corante Blogs examine, through the eyes of leading observers, analysts, thinkers, and doers, critical themes and memes in technology, business, law, science, and culture.

The Press Will Be Outsourced Before Stopped

Vin Crosbie, on the challenges, financial and otherwise, that newspaper publishers are facing: "The real problem, Mr. Newspaperman, isn't that your content isn't online or isn't online with multimedia. It's your content. Specifically, it's what you report, which stories you publish, and how you publish them to people, who, by the way, have very different individual interests. The problem is the content you're giving them, stupid; not the platform its on."
by Vin Crosbie in Rebuilding Media

Travels In Numerica Deserta

There's a problem in the drug industry that people have recognized for some years, but we're not that much closer to dealing with it than we were then. We keep coming up with these technologies and techniques which seem as if they might be able to help us with some of our nastiest problems - I'm talking about genomics in all its guises, and metabolic profiling, and naturally the various high-throughput screening platforms, and others. But whether these are helping or not (and opinions sure do vary), one thing that they all have in common is that they generate enormous heaps of data.
by Derek Lowe in In the Pipeline

Disrobing the Emperor: The online “user experience” isn't much of one

Now that the Web labor market is saturated and Web design a static profession, it's not surprising that 'user experience' designers and researchers who've spent their careers online are looking for new worlds to conquer. Some are returning to the “old media” as directors and producers. More are now doing offline consulting (service experience design, social policy design, exhibition design, and so on) under the 'user experience' aegis. They argue that the lessons they've learned on the Web can be applied to phenomena in the physical and social worlds. But there are enormous differences...
by Bob Jacobson in Total Experience

Second Life: What are the real numbers?

Clay Shirky, in deconstructing Second Life hype: "Second Life is heading towards two million users. Except it isn’t, really... I suspect Second Life is largely a 'Try Me' virus, where reports of a strange and wonderful new thing draw the masses to log in and try it, but whose ability to retain anything but a fraction of those users is limited. The pattern of a Try Me virus is a rapid spread of first time users, most of whom drop out quickly, with most of the dropouts becoming immune to later use."
by Clay Shirky in Many-to-Many

The democratisation of everything

Over the last few years we've seen old barriers to creativity coming down, one after the other. New technologies and services makes it trivial to publish text, whether by blog or by print-on-demand. Digital photography has democratised a previously expensive hobby. And we're seeing the barriers to movie-making crumble, with affordable high-quality cameras and video hosting provided by YouTube or Google Video and their ilk... Music making has long been easy for anyone to engage in, but technology has made high-quality recording possible without specialised equipment, and the internet has revolutionised distribution, drastically disintermediating the music industry... What's left? Software maybe? Or maybe not."
by Suw Charman in Strange Attractor

RNA Interference: Film at Eleven

Derek Lowe on the news that the Nobel Prize for medicine has gone to Craig Mello and Andrew Fire for their breakthrough work: "RNA interference is probably going to have a long climb before it starts curing many diseases, because many of those problems are even tougher than usual in its case. That doesn't take away from the discovery, though, any more than the complications of off-target effects take away from it when you talk about RNAi's research uses in cell culture. The fact that RNA interference is trickier than it first looked, in vivo or in vitro, is only to be expected. What breakthrough isn't?"
by Derek Lowe in In the Pipeline

PVP and the Honorable Enemy

Andrew Phelps: "Recently my WoW guild has been having a bit of a debate on the merits of Player-vs.-Player (PvP) within Azeroth. My personal opinion on this is that PvP has its merits, and can be incredible fun, but the system within WoW is horridly, horribly broken. It takes into account the concept of the battle, but battle without consequence, without emotive context, and most importantly, without honor..."

From later in the piece: "When I talk about this with people (thus far anyway) I typically get one of two responses, either 'yeah, right on!' or 'hey, it’s war, and war isn’t honorable – grow the hell up'. There is a lot to be said for that argument – but the problem is that war in the real historical world has very different constraints that are utterly absent from fantasized worlds..."
by Andrew Phelps in Got Game

Rats Rule, Right?

Derek Lowe: "So, you're developing a drug candidate. You've settled on what looks like a good compound - it has the activity you want in your mouse model of the disease, it's not too hard to make, and it's not toxic. Everything looks fine. Except. . .one slight problem. Although the compound has good blood levels in the mouse and in the dog, in rats it's terrible. For some reason, it just doesn't get up there. Probably some foul metabolic pathway peculiar to rats (whose innards are adapted, after all, for dealing with every kind of garbage that comes along). So, is this a problem?.."
by Derek Lowe in In the Pipeline

Really BAD customer experience at Albertsons Market

Bob Jacobson, on shopping at his local Albertsons supermarket where he had "one of the worst customer experiences" of his life: "Say what you will about the Safeway chain or the Birkenstock billionaires who charge through the roof for Whole Foods' organic fare, they know how to create shopping environments that create a more pleasurable experience, at its best (as at Whole Foods) quite enjoyable. Even the warehouses like Costco and its smaller counterpart, Smart & Final, do just fine: they have no pretentions, but neither do they dump virtual garbage on the consumer merely to create another trivial revenue stream, all for the sake of promotions in the marketing department..."
by Strange Attractor in Total Experience

The Guardian's "Comment is Free"

Kevin Anderson: "First off, I want to say that I really admire the ambition of the Guardian Unlimited’s Comment is Free. It is one of the boldest statements made by any media company that participation needs to be central to a radical revamp of traditional content strategies... It is, therfore, not hugely surprising to find that Comment is Free is having a few teething troubles..."
by Kevin Anderson in strange
In the Pipeline: Don't miss Derek Lowe's excellent commentary on drug discovery and the pharma industry in general at In the Pipeline

The Loom

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September 12, 2005

Monday Morning Buffet

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Posted by Carl Zimmer

I'm back from a computer-free vacation, and of course I have returned to mountains of emails and a long chain of fascinating new links. In place of any original thoughts of my own, let me just point you to a few things that look interesting (if you have any mental space not presently occupied by the horrors of Katrina).

1. Over the past couple years I've enjoyed watching Chris Mooney's blogging and articles evolve into a full-blown book, The Republican War on Science, which has just come out. Tonight he hits the big time tonight on the Daily Show.

2. Mooney is actually just part of the opening night of a week-long evolution series on the Daily Show. A couple years ago my wife and I decided to give up cable because we feared we'd be use up what little free time we had watching has-been celebrity biographies or movies about evil mechanical sharks. (I should point out that my wife is strangely immune to the lure of the mechanical sharks.) It's times like these, though, when I wish we still had just a little cable.

3. Human brains are evolving. Questionable Authority recaps. Will Bruce Lahn get the Nobel Prize someday?

4. Parasites are manipulating. Latest case: grasshoppers hurling themselves to their death on behalf of hairworms. Not a public health threat like malaria's sweet perfume, but very high on the science-fiction-meter.

5. Life on Titan? Astronomer David Grinspoon thinks all the raw ingredients are there.

Comments (4) + TrackBacks (0) | Category: Evolution


COMMENTS

1. cats on September 12, 2005 12:54 PM writes...

ah....I was wondering whether you got any trouble in Katrina disaster, since you didn't update your blog for a couple of days. And then you appears again.

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2. BC on September 12, 2005 01:36 PM writes...

It’s times like these, though, when I wish we still had just a little cable.

If you have a good internet connection, you can watch the daily show online (streaming).
http://www.comedycentral.com/shows/the_daily_show/videos/headlines/index.jhtml

And if you don't have a good internet connection, "Crooks and Liars" sometimes has downloadable copies of the Daily Show.
http://www.crooksandliars.com/

Permalink to Comment

3. Judith in Ottawa on September 13, 2005 10:36 AM writes...

Mooney did OK on the Daily Show, but was obviously scared to pieces! Stewart was kind but is naturally a bit forceful so the content didn't come off as well as one hoped.

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4. Wesley R. Elsberry on September 15, 2005 03:49 PM writes...

Let's recap another host induced to seek open water by a parasite:

How do people get Guinea worm disease?

People get infected when they drink standing water containing a tiny water flea that is infected with the even tinier larvae of the Guinea worm. Over the course of a year in the human body, the immature worms pierce the intestinal wall, grow to adulthood, and mate. The males die, and the females make their way through the body, maturing to a length of as much as 3 feet, and ending up near the surface of the skin, usually in the lower limbs. The worms cause swelling and painful, burning blisters. To soothe the burning, sufferers tend to go into the water, where the blisters burst, allowing the worm to emerge and release a new generation of millions of larvae. In the water, the larvae are swallowed by small water fleas, and the cycle begins again.

(Guinea Worm Disease Facts)

I recall a class visit to an agricultural research station where one of the staff discussed various nematode parasites. He noted the treatment for Guinea worm employed by the ancient Egyptians: lower the infected extremity into water, then when the worm extends out into the water, grab the end and wrap that part on a stick. Then, each day following, the worm relaxes a bit and another inch or two can be wrapped on the stick. Within a month, all of the worm is on the stick. I recall that someone asked whether modern medicine had improved on the technique. "Certainly," the staffer said, "now we wrap the worm on a stainless steel rod."

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