The Department of Health and Human Services recently announced additional funding for the neurotechnology research, development and enhancement program.

As I have written previously, neurotechnology is being driven by the convergence of advances in Nanotechnology, Information Technology, Biotechnology and Cognitive Science (NBIC -- pronounced N-bic). Mike Roco, the man who has spear headed the National Nanotechnology Initiative over the past decade, is now targeting the NSF's attention on creating a similiar initiative to understand how NBIC technologies will create new tools to enhance human performance.

I have grouped the examples used in the Neurotechnology Program Announcement into their respective technology sector to show that all four of these areas are required for neurotechnology to fully develop. I have also tried to find links to relatively close examples of each technology for those who wish dive deeper. (Many of these technologies could fall into multiple categories. For example, drug delivery systems are likely to require nanobiotechnology for significant breakthroughs to emerge.)

Neurotechnology Program Research Objectives

This program seeks to enable neuroscience and behavioral research by soliciting research and development of novel tools and approaches for the study of the development, structure, and function of the brain. Technologies that are appropriate include: hardware, software, and wetware (and combinations of thereof) that would be used to study the brain or behavior in basic or clinical research.

Nanotechnology
1. Nanocrystals or quantum dots covalently bonded to neural receptor ligands
2. Microfluidic systems for in-vivo spatial and temporal delivery of biomolecules
3. Microelectromechanical systems (MEMS) used for monitoring neurons
4. Nanoelectromechanical systems (NEMS) used for monitoring neurons
5. Amplifiers for mice to record neural activity from many neurons
6. Non-invasive optical imaging instruments
7. Tools for detection of acute neurological events
8. Improved electrodes, microcomputer interfaces, and microcircuitry

Information Technology
1. Software to translate neuroimaging data from one data format into another
2. Algorithms for understanding human neuroimaging data
3. Tools for real-time analysis of neurophysiological events
4. Dynamic monitors of intracranial pressure and spinal fluid composition
5. Devices for non-invasive diagnosis and precise identification of pathogens
6. Tools, technologies and algorithms for neuroprosthesis development
7. Non-invasive tools to assess damage, monitor function in brain tissue
8. Tools for data mining into genomics and proteomics of the nervous system

Biotechnology
1. Proteome analysis arrays, proteome data storage, analysis of proteome data
2. Genetic approaches to study structure or function of neural circuits in animals
3. Biosensors that would be selectively activated by neurochemicals
4. Delivery systems for drugs, gene transfer vectors, and cells
5. Probes of brain gene expression that can be imaged non-invasively
6. Genetic approaches to manipulate or monitor synaptic activity
7. Tools for intervention and prevention of acute neurological events

Cognitive Science
1. Non-invasive methods for in-vivo tracking of implanted cells
2. Tools to enhance visualization of specific brain markers
3. New methods to study neural connectivity in living or post mortem brain,
4. Tools for early-warning detection of imminent seizure activity
5. Methods to facilitate high-throughput analysis of behavior
6. Tools for therapeutic electrical stimulation for rehabilitation

Just as previous techno-economic waves have been driven by the convergence of multiple technologies from different sectors, so too will the neurotechnology wave. To understand how our emerging neurosociety may take shape, it is critical to understand how the NBIC convergence will drive the neurotechnology wave.

All thoughts and comments welcome. If there is a request I will start a NBIC wiki for those who are interested.