I traveled to the University of Pennsylvania yesterday to speak to graduate students and professors associated with the Center for Cognitive Neuroscience. Besides my talk that covered some of the social implications of the rapidly developing neurotechnology industry I had an opportunity to meet with several researchers doing some very interesting research. Here is a quick slice of what these researchers are up to:

Robert Forman: Impact of the Internet on distribution and delivery of legal and illegal drugs via the web. Persuasive research that will surely influence the drug importation debate.

Anjan Chatterjee: The historical analogies between the birth and growth of cosmetic surgery and cosmetic neurology. Very impressive parallels that include the dynamics of market forces.

Amishi Jha: Functional neuroimaging experiments on how neuropharmaceuticals and meditation influence similar aspects of attention in adult ADHD. Persistent meditation can improve focus.

Martha Farah: Director of the Center for Cognitive Neuroscience since 1999. Empirical examination of how a variety of neuropharmaceuticals impact "normal" individuals.

Paul Wolpe: Where to start? Busy bio-neuroethicist who is about to get a lot busier. Writing a book on biotechnical augmentation and ethics. Paul is a very bright individual and this book should be an important contribution. Told me to read the book Better Than Well.

While is was a quick 23 hour trip, it was well worth the time. It was especially nice to meet several students who drove down from Princeton for the talk. For more on the great research occurring at Penn I recommend visiting www.neuroethics.upenn.edu.

What separates artists and experimental scientists? Not much. This was the conclusion of last nights' Quantum Leaps panel discussion which included such luminaries as Bill Haseltine (retired Chairman and CEO of Human Genome Sciences), Martin Perl (Stanford's Nobel Winner in Physics - 1995), the hilarious Ivan Schuller, and the ever-witty moderator Bruce Jenett.

Despite one man's obsessive compulsive interrupting disorder, the two hour discussion dove deep into the value of contrarian thinking, the self-confidence and intuition required by both leading scientists and artists to create break new ground (in spite of the scientific method), and how obsession (the result of combining extreme intellect and emotion) is required to grapple with the unknown.

Bill Haseltine focused squarely on the future of medicine highlighting the regenerative model of human health that is emerging (via skin graphs, bone marrow transplants, and stem cells) and the tight integration and rapid development of bioelectronics (artificial hearts, prosthetic limbs) and neuorodevices (cochlear implants, optical implants).

Martin Perl posited several interesting questions:
1. What if mass is a trivial property in relation to understanding the universe?
2. What if gravity is not a smooth force as currently assumed?
3. Can we do time travel?

Ivan Schuller brought many laughs as he stripped down to his black t-shirt that had a multi-color version of the period table of elements. Ivan's main point was that experimental scientists need to have the freedom to explore their obsessive concerns without the need to explain exactly what the value of their work will generate in terms of economic gains. In terms of his current research on nanosystems he declared, "Don't ask me why it's valuable, we won't know this for many years to come."

Bruce Jenett interjected at several points to illuminate the discussion, ending with the profound thought of asking the audience to explore what part of themselves they would like to modulate if they could. As Bruce reminded all of us, "Yesterday's magic is today's science is tomorrow's commodity." Snap, snap.

People everywhere say that they have had out-of-body experiences. (Follow this link to read people's stories).

In this week's Journal of Neuroscience, Blanke et al. attempt to link the phenomenon known as an out-of-body experience (OBE) with specific brain activity. During an OBE, one senses that the "self" departs the body so that the body and the world can be viewed from "outside." Healthy volunteers imagined an OBE, mentally shifting their visual perspective and body position. Evoked potential mapping revealed selective activation at the temporoparietal junction. It seems that out of the body is not necessarily out of the brain."

So maybe the phrase "In Neurons We Trust" isn't that far off the mark. Special kudos to the research team: Olaf Blanke, Christine Mohr, Christoph M. Michel, Alvaro Pascual-Leone, Peter Brugger, Margitta Seeck, Theodor Landis, and Gregor Thut

"Science and Society" is a must hear radio broadly focused on the life sciences, physical sciences, and planetary and space sciences, as well as K-12 science education and the intersection between science, art and society.

Catch the conversation tomorrow, Wednesday, 1/12/05, 1PM PST. (click here)

- The Honorable Phillip J. Bond, Under Secretary of Commerce for Technology
- Dr. Steven Wiley, Director, Biomolecular Systems Initiative, Pacific Northwest National Laboratory
- Dr. Karin D. Rodland, Staff Scientist & Technical Group Lead, Protein Function, Pacific Northwest National Laboratory.

Management Craft is kicking off the New Year by hosting this week's Carnival of the Capitalists. Be sure to check it out. If you want to participate in the next one, visit this website for the submission form.

This week’s theme is Brains and Hearts - How we Use our Brains and Hearts as Tools of Progress and Meaning. Looks like I got lucky when I submitted by blog on mental health and neurocompetitive advantage. I also recommend Tom Peter's short post on New Year's Resolutions.

Here is a brief review of the talk I gave last week in Dubai which was also covered in the Gulf Today:

"Providing 'A Peek into 2050' noted futurologist Zack Lynch predicted that 'Neurotechnology' will be for the future what Information Technology is for the present.

He explained that neurotechnology has already begun to be tested to enhance the productivity of workers. It is a method to analyse the brain and enhance its performance. It has three tools - brain imaging, neuropharmaceuticals and neurodevices."

More insights from the Forum soon.

"Our region is at crossroads and our fates are inexorably tied. We can either succeed together or fail together. We can choose to erect barriers that stifle growth or forge new alliances that create opportunities. The Arab Strategy Forum is about the latter. It is about dialogue, debate and networks that create new opportunities for peace, progress and prosperity for our common region and our common future. It has been set up for the region, by the region.

I look forward to welcoming you to Dubai and hope you will be part of this momentous cause."
- HH Sheikh Mohammed Bin Rashid Al Maktoum

20 years ago I visited Dubai and it changed my life. Today I am leaving San Francisco with my wife and returning to Dubai to give a keynote talk at the Arab Strategy Forum on our emerging neurosociety. The central theme of the meeting is The Arab World in 2020 and I have been invited to share my perspective on Tomorrow’s World: A Peek into 2050 at the gala dinner on the second night.

It is an honor to be speaking with so many esteemed individuals, including: Former President Bill Clinton; Thomas Friedman; Madeleine Albright; Laura Tyson; Gideon Rose (Editor, Foreign Affairs); Prince Turki Al Faisal (Saudi Arabia); Jassim Al-Mannai (Chairman of the Arab Monetary Fund); Prime Minister Abdullah Badawi (Malaysia); Rafiq Al Hariri (Former Prime Minister of Lebanon); Prime Minister Shukri Ghanem (Libya); Hoshyar Zebari (Foreign Minister, Iraq); Fouad Ajami (Johns Hopkins); Juliette Kayyem (Harvard); Mohamed M. ElBaradei (Director General, IAEA); Fareed Zakaria (Editor, Newsweek); AbdulRahman Bin Hamad Al-Attiyah (Secretary General, GCC); Samir Al Ansari (CEO, Dubai International Capital); and many more key stakeholders.

The goal of the meeting is to advance the state of the Arab Region by bringing together key regional stakeholders to engage in activities that bridge differences and build opportunities for growth and prosperity in the region.

The invitation to speak came from a paper Tim-Rasmus Kiehl (a Harvard neuropathologist and long time Brain Waves reader) and I spontaneously wrote in September titled "The Neurotechnology Nexus: Opportunities for Dubai as a Leading Cluster of Converging Technologies." No one requested this information. We wrote this paper for one simple reason: to share the knowledge about how neurotechnology will impact business, politics and global culture in the years to come with those who are focused on the critical issues facing today's world. I am extremely honored and humbled by this opportunity and look forward to sharing my experiences upon my return.

I am extremely honored to be giving the keynote talk at this year's Arab Strategy Forum that will be held from 13 - 15 December 2004, in Dubai, UAE. The central theme of the Forum will be 'The Arab World in 2020'. Discussions will focus on three major axis, Arab Governments in 2020, Arab Economies & Businesses in 2020, and Arab Societies in 2020. My keynote talk at the Gala Dinner on December 14 will focus on "Tomorrow’s World: A Peek into 2050."

The invitation was graciously extended by the Executive Office of His Highness General Sheikh Mohammed Bin Rashid Al Maktoum Crown Prince of Dubai and UAE Defense Minister with additional support from Mr. Saeed Al Muntafiq, Director General of Dubai Development and Investment Authority.

It has been almost 20 years since I have visited Dubai. Under the leadership of the UAE's first President, who passed away last week, His Highness Sheikh Zayed Bin Sultan Al Nahyan and the country's other progressive leaders like Sheikh Mohammed, the country has established an impressive record of rapid economic and social development, including: Dubai Internet City (where 65% of the workforce are women), Dubai Media City, Dubai Knowledge Village, Dubai Health Care City, and the Dubai's e-government portal, the world’s first fully online government.

I look forward to sharing with the Forum participants a hopeful and realistic peek into our common future.

His Highness Sheikh Zayed Bin Sultan Al Nahyan, President of the United Arab Emirates, was laid to rest on Wednesday evening at a site in the Zayed Grand Mosque as millions mourned his passing.

Known as the Arab Sage, Sheikh Zayed will be remembered for his focus on long-term political-economic development, equality of women, inter-faith tolerance and compassion for his people. He was a beacon of hope throughout the world that will shine on for many decades.

"A nation without a past is a nation without a present or future," he once said. "Thanks to God, our nation has a rich past with a flourishing civilization, deep-rooted in this land for many centuries. These stable roots will always flourish and bloom in the glorious present of our nation and its anticipated future."

The Supreme Council of the Emirates, which comprises the leaders of the seven constituent emirates, their brothers and their crown princes, held a meeting and unanimously elected Sheikh Khalifa bin Zayed al-Nahyan, ruler of Abu Dhabi, as its president Wednesday, hours after burying his father.

Sheikh Zayed was the first and only president of the UAE, which was formed in 1971. He was strongly revered by Emiratis and other Arabs across the Middle East.

Christopher Reeve (Sept. 25, 1952 - Oct. 11, 2004)

"Look, I've flown, I've become evil, loved, stopped and turned the world backward, I've faced my peers, I've befriended children and small animals and I've rescued cats from trees," Reeve told the Los Angeles Times in 1983, just before the release of the third "Superman" movie. "What else is there left for Superman to do that hasn't been done?"

"I refuse to allow a disability to determine how I live my life. I don't mean to be reckless, but setting a goal that seems a bit daunting actually is very helpful toward recovery," Reeve said after his 1995 horse-riding accident that caused his paralysis.

--- Christopher Reeve's inspiration is beyond words.

MIT has chosen Susan Hockfield, a neurobiologist who is currently provost at Yale University, to serve as its sixteenth president. Hockfield will succeed Charles M. Vest, who has led MIT for the past 14 years. She is expected to take office in early December, and will be the first woman and first life scientist to hold the post.

Congratulations to Susan and to MIT. I've been following her career for several years and she fits perfectly with the McKnight Foundation's strong commitment to accelerate the development of neuro-oriented research.

Nobel laureate Susumu Tonegawa, an MIT biology professor who served on the faculty advisor committee for the presidential search, says that Hockfield has achieved international fame as a neuroscientist. “On a personal level, she has an uncanny knack of making people feel at ease and is a great and thoughtful listener. She is a charismatic figure who we will be proud to have represent MIT on the national and international stages,” says Tonegawa. He adds that Hockfield's appointment will "accelerate the demise of the gender barrier in science and engineering.”

While MIT continues to push further into developing the technical aspects of our emerging neurosociety, Stanford's Judy Illes continues to break new ground in neuroethics. Perhaps it's time to endow the new program for neuroethics at Stanford. Please contact Judy or me if are interested.

We live in a 24 hour society. Perhaps we should have some better tools.

New insights on causes of jet lag and shift work disorientation (from innovation-report)

Timing is everything and our circadian clock, allows us (and almost every other organism on the planet), to predict the daily changes in our environment, such as light and temperature. One of the most important functions of the circadian clock is its ability to react to and predict environmental cues, light being the most important, keeping the endogenous clock in phase with the external light-dark cycle (entrainment). Cryptochrome is a light-sensitive protein that is the key to entrainment.

“During our experiments we also noticed that a particular group of neurons were especially affected by the continuous subjective light stimulation. This unprecedented observation allowed us to integrate several threads of circumstantial evidence from previous studies, and implicate this group of neurons as main players in the entrainment of the Drosophila clock.”

How might help the paradox of globally distributed teams?

Knowledge management is a joke and search technologies are overrated.

It was about ten years ago that I really began to understand the adage, "you can't manage, what you can't measure." It was the early Internet days, when companies like CyberCash were promising micropayment systems for e-commerce, Yahoo was establishing the first search/portal system and supply-chain vendors like i2 Technologies were beginning to leverage TCP/IP to rearchitect information flow among disparate factory planning systems. It was then that I realized emerging knowledge management applications had (and still have) a fundamental flaw: they don't measure the value of information. Without knowledge valuation you can't have knowledge management.

To realize the productivity potential of information technologies will require information valuation. By historical analogy, it is as if we are in the middle of the industrial revolution and we don't know the cost and price of steel. Today we sit in the midst of the information revolution and still don't know the value of the most fundamental resource that drives our global economy: information. The benefits of the information revolution won't be realized until bottom-up, market-based valuation of daily information exchanges emerges.

Seven years ago, I shared this concept with Shanda Bahles of Eldorado Ventures. Three years later she gave me a call and asked me to come back in to explain what an information valuation system would look like to the partners. For the next six months Ross Mayfield and I worked day and night developing a business strategy for infecting the world with this technology. It was early 2001, and the venture investment community was, to say the least, not investing in "radical, unproven technologies." So we shelved our business plan. The world was not yet ready to value their time.

Several recent events make me think that the world might just be ready for information valuation. For example, the interest in using prediction markets and idea futures within companies to optimize resource allocation and sales forecasts are gaining momentum. While I still think it will be a few more years until robust systems are developed, I am more optimistic than ever that knowledge measurement systems will emerge. The reason is simple: search can only go so far.

Search technologies, no matter how sophisticated, can't capture the implicit value that humans inherently place on information and relationships. Today "search technologies" continue to command great attention and funding (Google) as "the solution" to the "info glut" problems that arise from working in an information economy.

While I won't go as far as to say that "search is dead," I certainly believe that in the next decade it will be relegated to a background function, as information valuation technologies allow simple, seamless ways for individuals to place a monetary value on every form of information they encounter each day. Bottom-up information valuation of highly nuanced information will enable markets in everything. In the process, information valuation will transform the future of work, organizational cultures, eliminate information overload, and finally make knowledge measurement (and thus management) a reality.

Neurowarfare is a very real and growing threat. In an effort to accelerate new drugs and vaccines against potential bioterror weapons including anthrax, smallpox, plague and the Ebola virus, the House of Representatives approved last week a $5.6 billion anti- terrorism initiative called Project Bioshield.

While American's focus on bioweapons, other governments are making headway on new ways to stem deadly the impact of neuroweapons. This week at Singapore International Neuroscience Conference, researchers from DSO National Laboratories presented new findings that showed how epidural clonidine is used with two other drugs it can protect brain cells from being destroyed by nerve agents, like sarin gas. Preliminary tests showed that the combination reduces brain damage significantly and does not cause breathing complications, thus increasing survival rates, compared to the cocktail now used in situations like the 1995 sarin gas attack in Tokyo subways by members of Japanese cult Aum Shinrikyo.

As the Strait Times reports, "While the new combination has been shown to protect most of an affected person's brain cells even when administered as much as 40 minutes after he is poisoned by biochemicals...the potential downside is that it could lead to psychosis, a mental disorder where the person loses touch with reality, and lead to his being on medication for life." Given these complications, the researchers stated that it will take at least another six to eight years of testing to determine if the new combination should replace the existing one.

Brain Wave's guest blogger Pat Kane, author of "The Play Ethic: Living Creatively in the New Century," has been neofiled. I highly recommend reading his interview and buying his book about the future of work which he suggests will be...well, fun. Here is one of the pieces he wrote a while back:

By Pat Kane

[As promised, Pat Kane, author of the forthcoming book "The Play Ethic: Living Creatively in the New Century (MacMillan 2004), is guest-blogging on Brain Waves this week as Zack Lynch begins the heavy lifting of writing a book of his own.]

It’s a delight to be in this space, as I’ve been an admirer of Zack’s diligent and intelligent blogging for a while now. But it’s perhaps best to start by explaining why a social commentator and musician/consultant/activist like myself, with at best a fan-boy enthusiasm for the Third Culture crossover between humanities and science - is interested in the issue of "neurosociety" (never mind neuro-sociology).

Zack's entry on the neurophysiology of laughter and humour was the main point of contact with my own interest, expressed in my website and forthcoming book The Play Ethic. The title started out as a kind of pun on Max Weber's notion of the Protestant Work Ethic, but has expanded into a multidisciplinary passion for understanding human play in all its forms, traditions and conditions.

One of the reasons I turn to cutting edge mind-science - and admittedly to its more dynamical and emergent than determinist models - is that I'm always trying to unsettle the reductive model of human nature and its capacities implied by the "work ethic", particularly as deployed by opportunist politicians and other neo-Puritan miserables. To be "at play and in play" is not only to have a mentality that is far more suited to a knowledge-intensive information economy: but it's also to deliberately embrace the essential abundance of human consciousness.

The "ethics" of play then become an answer to the old question stated in the 1968 edition of the Whole Earth Review: "We are gods, and we might as well get good at it." This is a world which is ever more constitutively "open" and up for grabs - whether in terms of what Zack calls the "nano-bio-info-cogno" realm of transformative technosciences, or the extreme fluidity of our globalised markets and cultures. Can we become "ethical players" of all these possibilities - rather than cynical manipulators of them, or defeated and angry victims?

So one reason for me to be interested in Zack's agenda is precisely in the area of the cognitive capacity and emotional evolution of the ethical player. (The wisdom contained in the "technologies of self" we often call spiritual traditions - see Francisco Varela and Erik Davis - is another agenda worth exploring). To cope with this carnival universe that we've made, is it enough - as the some evolutionary psychologists would tell you - to rely on the old hominid responses: that repetoire of savannah inheritances, tragic and comic, that have become a consoling pop-science myth for so many people?

Or can we begin to explore, as so much of Zack's linking does, the scary but exciting area of neurosocial innovation? Might carefully-calibrated drugs open new doors of perception, enabling players to participate in all the ramifying games and strategies of information societies, rather than recoil from its chaos and complexity? Certainly, in a society where play became a mainstream rather than a marginal practice, the inhibitions on pursuing cognitive and somatic enhancement would be much reduced, particularly in terms of research investment. (In one of my own specialist areas - music - the relationship between craft, technology, innovation, consciousness and, er, "neuroceuticals" (well, that's one word for them) has long been explored in practice: I hope to pick that up, among other themes, over the next few days).

Any comments and questions, I'd be very happy to receive them.

FuturePundit blogs about Glenn Reynolds' Aubrey de Grey interview at TechCentralStation, and forgets his own recent post about the need for better tools for mental health that will be required by long living humans.

Several months ago Dr. Rajaram contacted me from India about an idea he had to utilize neurotechnology to improve software engineering productivity. The following is a paper he has written about the project. He is currently looking for sponsors and will be visiting the U.S. in mid-June (in New York On June 11 and in SF on the 21st).

Written by L.N.Rajaram, PhD

The average experienced programmers inject as many as 10 defects in 100 lines of code, spending more than 40% of their development time finding and fixing defects.

There are many reasons for writing software in such an inefficient manner including inexperience, incompetence, and the intrinsic complexity of the problem to be solved. The most common reason is an inexplicable tendency to discard proven prescribed practices of systematic effort and indulge in practices that Watts Humphrey calls as those of 'American Cowboy Programmers'. This style is popular with even some experienced programmers and is characterized by a sporadic mixture of 'code-a-bit, test-a-bit' (called CABTAB) set of unplanned activities.

Many attempts have been made to stop such practices by introducing several organizational models, standards and certifications. The most effective of these have been the Personal Software Process and the Team Software Process of the Software Engineering Institute, as these address issues at the level of individuals and teams that develop software. The emphasis is on individuals planning their activities and working according to their plans. Such disciplined way of working has shown astounding results and those who for some reason have undergone such training and have seen their individual performance improve remain converted to that style of programming.

However, the crunch is in getting people to realize that there is a need to improve, to get them to undergo this training and to inculcate a discipline of self restraint against tempting short cuts that are actually counter productive.

There is a persistent delusion that software complexity can be overcome with some heroic intellectual effort. A kind of folklore romanticism exists amongst the software community that they are the intellectual cream of the society and can overcome all challenges by the sheer power of their brains. However, the evolutionary origins of the human brain suggest that it is not designed to tackle the challenges faced in software development. The mind is involved in sporadic switching between the real world problem and its symbolic representation, between high level conceptual abstraction and low level procedural detail, between the ambiguity and hence flexibility in user requirements and the rigidity of a dumb machine. The mind is ill equipped to handle this complexity and requires help. The evolutionary psychologist Leda Cosmides sums it up very succinctly in Our modern skulls house a stone age mind.

The 'triune brain' proposed by Paul Mclean is fascinating. The model talks of evolutionary layers of brain. The brain stem is a reptilian relic and forms the lowest layer and is primarily responsible for controlling body's basic metabolic functions, like heart rate and breathing. On top of that is the second layer known as paleo-mammalian brain, also known as the limbic system. This is the seat of emotion and memory, comprising the amygdala, the hyppocampus and the hypothalmus. "Our primary emotions, love and fear, sadness and joy-emerge from this region, coloring incoming stimuli with emotional valences we have associated with past events stored in the hyppocampus or the amygdala." The top most layer is the neo-cortex. This is the most distinctly human and evolutionarily youngest component of the brain's architecture. Only primates have something similar. The cortex is the seat of abstract thought, long term thinking and complex communications.

It is obvious that the cortex has a very big role to play in an objective and rational intellectual process required for software development. Within the cortex there are different centers that process sensory information, do mathematical abstraction, language and symbolic abstraction and construction, fill-in missing information by sub-consciously extrapolating known facts, implied contexts and so on. Different circuits come into play during different levels and types of abstractions undertaken while formulating software requirements, design specifications, detailed level logic and algorithms and while implementing the code. Disciplined methods of software programming help in the predominant functioning of one or the other part of the brain and the 'cow-boy style programming' encourages the unstructured chattering of different parts of the brain bidding quick-fix solutions.

But we have a more serious problem than the incoherent functioning of the different parts of the rational brain. Software work like all other work does carry the attendant emotional baggage. There is fear of failure, need for peer recognition, expectation of reward, competitive pressure. Thus the limbic system also climbs on to the center-stage of the orchestra in the mind involved in software development. The Stroop Interference Test enables us to appreciate how difficult it is concentrate on any one aspect and to stop one's brain from thinking different things. It is indeed a wonder that the human brain has had so many intellectual achievements to its credit, in spite of its 'primitive' design.

Until the maturing of the software industry in the last couple of decades, a very insignificant fraction of the society has been involved in intellectual pursuits. For the first time in the history of mankind millions of people are involved in the type of intellectual activity characterized by the knowledge economy. Hence it has become very critical to find ways of routinely enhancing the intellectual productivity of large representative sections of society not specially endowed with extraordinary abilities. These neuro-feedback techniques have to augment the ongoing efforts of evangelizing disciplined software methods.

The application of neurotechnology could provide us with a 'head cap' that provides us with a feedback to help us monitor our brain activity. With the help of this feedback, individuals can be trained to willfully chose and restrict activity to the most effective part in the brain to deal with the specific aspect of the software problem at hand. The feedback can be used to prevent the cacophony of all the parts of the brain to drown us in an overkill of rationality and emotions. Several experiments in different contexts have been reported to localize and even measure the electrical activity in different parts of the brain of a subject to see its correlation with what the subject was thinking at that time. Steven Johnson has reported in his book 'Mind Wide Open' as to how he could calm his mind to 'pay attention to one specific aspect and shutting out other activity by the observing the feedback obtained by measuring his 'Theta waves'. Many sports persons have benefited by this technique and great ones like Tiger Woods seem to have a natural ability to shut out all unrequired rational thought while performing.

I propose that several areas of research be undertaken to ultimately understand how software productivity can be enhanced with a better understanding and monitoring of brain activity. To start with I propose that several subject programmers be asked to volunteer to study the activity pattern in their brains under controlled conditions. The conditions could be varied systematically by first having volunteers who practice disciplined software methods and have a proven track record of very good results. Secondly, the volunteers could be drawn at random without any previous coaching in disciplined methods. They could then be subject to other conditions such as stress of schedule, reward, ridicule, etc. A correlation between the use of best practices, the spatial and temporal distribution of brain activity and the quality of software and individual productivity could be established.

This study could then lead to applying the results to train intellectual workers to enhance their concentration on one aspect of the problem and thus improve their productivity. By observing the impact of stress and other emotional aspects, the work environment including the corporate set-up can be reengineered to suit this kind of work.

If we could get an insight into how to help individuals write defect free software to a far greater degree than the prevailing state of art we would have unlocked a major productive force that could make this world a far better place to live in. If you are interested in learning more about this project please contact me directly at (rajaram-at-webcalltech-dot-com)

"The empires of the future are the empires of the mind."
~ Winston Churchill, September 5th, 1943

Amsterdam, 23 April 2004 - “Brains sciences are not only about treating diseases, they form an important narrative about what it is to be human. That is why it is important to have a societal discussion about what is going on in the field,” said Andreas Roepstorff, a medical anthropologist from the University of Aarhus (Denmark). Roepstorffs’ statement was one of the important conclusions of the expert-stakeholder workshop ‘Connecting Brains and Society, the Present and Future of Brain Sciences: what is possible, what is desirable?’

This summary of the meeting put together by Peter Raeymaekers, Karin Rondia and Marjan Slob. It is the first in a four part series covering the key topics discussed at the meeting.

The meeting represented the overture of the European Citizens Deliberation project. Before involving citizens in the discussions on brain sciences, the members of the steering committee of the ECD felt that an overview of the technological and societal aspects of brain sciences was needed.

A Timely Topic

A citizen’s debate on the different aspects of brain science was welcomed by all participants of the workshop. “Considering that 35% of the burden of all diseases is caused by brain diseases, these diseases have received relatively little attention,” said Jes Olesen, president of the European Brain Council.

-- Is there enough teaching of neuroscience and brain diseases at medical and nursing schools?
-- Is a reasonable proportion of research funds allocated to basic and clinical neuroscience?
-- Are the efforts in prevention, primary care and hospital treatment sufficient?

The huge burden of brain diseases requires a response to all these questions. Society must also address the fact that the burden of brain diseases will further increase in the next 10–20 years.

Baroness Susan Greenfield, director of the Royal Institution of Great Britain, considers brains sciences a timely topic for debate, “Appreciating the dynamism and sensitivity of our brain circuitry, the prospect of directly tampering with the essence of our individuality seems to become a possibility.”

A well selected group of 25 European top level scientists and stakeholders were invited to this informative workshop to give their views on the developments in brain sciences from their own perspectives. Among them physicians, neuro-, psychiatric, cognitive and social scientists, philosophers, artists and representatives of stakeholder organisations – i.e. the pharmaceutical industry, the European Brain Council, the European Federation of Neurological Associations and the Global Alliance of Mental Illness Advocacy Networks, and The European DANA Alliance for the Brain. Unfortunately, the president of the Federation of the European Neuroscience Societies, Pierre Magistretti, was in the end not able to attend the workshop. But CCLE's Wrye Sententia attended from the USA to discuss our emerging neurosociety.

How does a mind arise from the biology of the brain?

What are the neural bases of cognition, personality, and self-awareness?

How can we characterize intelligence and creativity from an interdisciplinary perspective?

What are the limits of nervous system plasticity in cognitive function, and how does training influence cognitive-neural organization?

If you are interested in these questions, then you should know about the new Center for Mind and Brain at UC Davis.

If you missed Natasha Mitchell, host of Australia's weekly national radio program, All in the Mind, interview me about The Coming of the Neurosociety, the transcripts are now available.

Here is an excerpt :

Zack Lynch: Currently the United States has recently implemented fingerprinting people as they come into the United States from certain countries. If they have the capacity to do brain finger printing should that be done, is there a right for individuals, Americans, or foreigners to have brain privacy? Where is that edge in a neurosociety?

Natasha Mitchell: Where indeed? Hello Natasha Mitchell with you for All in the Mind. This month sees the release of another surreal offering from screenwriter Charlie Kaufman with the film Eternal Sunshine of the Spotless Mind. The film has stars Jim Carey and Kate Winslet selectively erasing their minds of memories of their tumultuous relationship with the help of a maverick scientist and a whiz bang piece of neurotechnology.

Extract from the movie Eternal Sunshine of the Spotless Mind trailer:

They are erasing you Clem you’ll be gone by morning.

Natasha Mitchell: Yes, well it sounds improbable though not according to my guest today who believes that the rapid convergence of nanotechnology, cognitive science, biotechnology and information technology, which all gets abbreviated to 'Nano-Bio-Info-Cogno' by the way, will have major consequences for how we think and behave.

You might have read recent headlines championing the arrival of the next big thing in the advertising world, Neuromarketing - just one example of the prospects for neurotechnology. It’s an attempt to find the 'brain’s buy button', so they say, and the idea is to scan our brains, measure cerebral blood flow to find out what our subconscious minds really feel about a product and to tailor ad campaigns accordingly.

The hype around it all has been palpable and keeping a keen eye on it is Zack Lynch who’s Executive Director of a non-profit organisation he’s founded called the Neurosociety Institute and he also runs a popular net blog called Brain Waves – Neurons – Bits and Genes, exploring technologies that target the contents of psyche and beyond. And Zack joins me today on All in the Mind.

Zack Lynch thanks for joining me on the program from there in San Francisco.

Zack Lynch: Well thank you for having me.

Natasha Mitchell: You think we’re on the cusp of yet another major societal transformation, you suggest that we’re heading towards a neurosociety. What is a neurosociety?

Zack Lynch: Well if we look back through human history what we see is we’ve come from an agricultural society to an industrial society, today we’re living in an information society where political, economic, social changes, basically driven by information technology. If we look forward what we see is the convergence of multiple technologies that will allow us to develop effective tools for mental health. Now those tools are neurotechnology, the set of tools that allow us to manipulate our central nervous system, more specifically our brain. Our future society will be driven by neurotechnology. Now that’s brain scanning technologies, neuroceuticals, which are advanced psycho-pharmaceuticals and those will create new industries. They will have political, economic and major ethical implications.

Natasha Mitchell: You paint a pretty grandiose vision, I’ll come to neuroceuticals in a minute because that’s an intriguing possibility – you suggest that neurotechnology has the potential to redefine competitive advantage, restructure patterns of global production and make possible new modes of artistic expression. I mean to some ears this all sound rather improbable.

Zack Lynch: Sure, with any new technology there’s always promise and peril; it’s a double-edged sword. Now I think it’s important to know that when I talk about the neurosociety what we’re really talking about is a time from about 2010 to 2060. This isn’t something that’s occurring now so when you’re looking at how brain scanning technology is and neurotechnology is in its current state today.

Natasha Mitchell: Positively antiquated.

Zack Lynch: Correct, absolutely, as I like to say, Prozac is the wheel!

FutureLab: The Innovation Expo is currently traveling to high schools around the U.S. previewing advanced technology exhibits in the areas of: Deep Space, NanoFutures, Beyond DNA and RoboTech. FutureLab’s goal is help teens understand how science will shape ltheir lives and future job prospects.

After only two stops, FutureLab has reached over 12,000 students. To see if FutureLab will be coming to a high school in your area check here.

James Canton, CEO of the Institute for Global Futures, is interviewed in US News' Friday Forward column where he describes some of the critical issues he sees emerging in the coming decades. Here is a snippet:

"Next News: What trends do you see developing over the next 10 to 25 years that the average person today has little awareness of?

Canton: I get Issues in Science and Technology, I subscribe to the NeuroSociety Online Blog by Zack Lynch and I get NASAs Astrobiology newsletter."

As I've mentioned before, James gets it.

The London Financial Times named Pat Kane this week's Guru for the ideas he has put forward in forthcoming book, Play Ethic: A Manifesto for a Different Way of Living.

Pat was a guest blogger on Brain Waves last year writing several brilliant pieces, including:

- The Play Ethics and Neurosociety
- No Innovation without Representation
- To the Victor the Paradoxes
- "Quirky, Flexible, Redudant": the Being and Becoming of Play

As he explains in the Financial Times and on his own blog, "We should stop thinking of playing as a distraction and start celebrating its benefits, such as added creativity, flexibility and dynamism. We should also redefine the way we think of ourselves and label ourselves "players" not "workers."

I highly recommend Pat's Play Ethic blog if you haven't been there already. Also, check out what the Guardian had to say about him.

Marginal Revolution caught this great blog about what life was like 100 years ago in the US.

- Average life expectancy was 47.
- Only 14 percent of homes had a bathtub.
- Only 8 percent of the homes had a telephone.
- There were 8,000 cars and just 144 miles of paved roads.
- More than 95% of all births took place at home.
- 90% of all physicians had no college education.
- Most women only washed their hair once a month
-The five leading causes of death were: 1. Pneumonia & influenza 2. Tuberculosis 3. Diarrhea 4. Heart disease 5. Stroke
-And the kicker: The population of Las Vegas, Nevada was 30.

So what will 2104 look like? Sure makes our emerging neurosociety seem more likely, eh?

The nascent neurotechnology wave (2010-2060) is being accelerated by the development of biochips and brain imaging technologies that make neurological analysis inexpensive and pervasive. Biochips that can perform the basic bio-analysis functions (genomic, proteomic, biosimulation, and microfluidics) at a low cost will transform biological analysis and production in a very similar fashion as the microprocessor did for data. Nano-imaging techniques will also play a vital role in making the analysis of neuro-molecular level events possible. When data from advanced biochips and brain imaging are combined they will accelerate the development of neurotechnology, the set of tools that can influence the human central nervous system, especially the brain. Neurotechnology will be used for therapeutic ends and to enhance human emotional, cognitive and sensory system performance.

Lynch's 15 Laws of the Neurosociety

1. Lynch's Law of Social Forecasting

By viewing recent human history as a series of techno-economic waves with accompanying socio-political responses it is possible to understand the type and timing of how new technologies will shape our future human society.

2. Lynch's Law of Future Societal Change

Neurotechnology will drive the next fifty year wave of societal change, the neurotechnology wave 2010-2060.

3. Lynch's Law of Neurotechnology

Neurotechnology, the set of tools that influence the brain, are being driven by nanobiochips and brain imaging technologies that will make neurological analysis inexpensive and pervasive.

4. Lynch's Law of Nanobiochips

Nanobiochips that perform the basic bio-analysis functions (genomic, proteomic, biosimulation, and microfluidics) at a low cost will transform biological analysis and production in a very similar fashion as the microprocessor did for data during the information technology wave. Unlike Venter's Second Law, the cost of biochips will decline even more rapidly because they will be the driving low cost product that will transform every industry. Nanobiochips will emerge around 2012.

5. Lynch's Law of Human Brain Imaging

Nano-imaging techniques will make possible real-time analysis of neuro-molecular level events in the human brain. The brain imaging bottleneck will be broken around 2015.

6. Lynch's Law of Neuroceuticals

When data from biochips and brain imaging are combined they will enable the development of neuroceuticals. Neuroceuticals are tools that will reduce the severity of mental disorders and improve mental health.

Neuroceuticals can be broadly categorized into three classes:Cogniceuticals, Emoticeuticals, and Sensoceuticals.

7. Lynch's Law of Neuroceutical Development

Today's pharmaceutical development process where a new drug can take 15 years and can cost over $800m. By 2020 new neuroceuticals will take less than 2 years to develop and cost under $10m. Details of pharma's industrial implosion in chapter 4 of my forthcoming book, Neurosociety.

8. Lynch's Behavioral Law of Neurotechnology (Perception Shift)

By influencing multiple personality characteristics, neuroceuticals will shape how people perceive daily issues. New behaviors will emerge that culminate into a substantially different behavior repertoire than people currently encounter. A person who is slightly less depressed, slightly less anxious, slightly more aware, and with slightly better recall behave differently than people do today.

9. Lynch's Law of Human Performance Enablement

By improving economic productivity countries will legalize performance enhancing tools by 2020. This shift will come with the understanding neuroceuticals are the latest set of tools, in humanity's long history of tool building, that enable individuals to live, live longer, and live happier.

10. Lynch's Law of Neurocompetitive Advantage

Neurotechnology represents the next form of competitive advantage beyond information technology. For example, innovation is a complex mental function wherein cognitive assessment and emotional compassion combine to accelerate the creation of new knowledge. Individuals that utilize neuroceuticals (say to forecast emotions) will become more productive and creative will attain neurocompetitive advantage.

11. Lynch's Law of Regional Economic Development

Neurotechnology clusters will emerge in India and China first because the political and cultural views on human testing won't impede technological experimentation and development.

12. Lynch's Law of the Neurosociety

Neurotechnology will give rise to a new type of human society, a post-industrial, post-informational, neurosociety.

13. Lynch's Law for the Survival of Humanity

Empathy

14. Lynch's Personal Law of Life

People do the best they can with the resources they have.

15. Lynch's Personal Law for Life

Give more, get more.

Yesterday I spent the day with 300 others at IBM's 2004 Almaden Institute conference. Jim Spohrer invited me to listen about the following topics by some leading thinkers, including:

1. The Future of Work -- Thomas Malone (MIT Sloan School)
2. Changing Ways of Working? -- Graham Button (Xerox Research Centre)
3. Strategic Issues Linking US and India-based IT Workforces -- Dossani (Stanford)
4. Empowering the World's Poor Through IT -- Mohamed Muhsin (World Bank)
5. Cross-cultural Issues in Global Software Outsourcing -- Geoff Walsham
6. The Geopolitics of Shared Cognition in Globally Distributed Teams -- Marietta Baba (Michigan State University)

Unfortunately, even at IBM's premier research center, wi-fi access was spotty, so I lost some of my notes on a few of the talks because of getting kicked off the wireless network. A classic problem that all conferences, like the Always-On Conference had last year.

Defining a Global Distributed Team (GDT) as an interdependent workgroup comprised of cultural diverse members based in two or more nations who share a collective responsibility for making or implementing decision related to a firm’s global strategy was Marietta Baba In her analysis these team also relied on technology as a medium for communication and coordination.

For GDT's to work successfully members share and integrate explicit and tacit knowledge and create new knowledge that adds value. In this case Knowledge is defined as aspect of cognition whose accuracy or correctness has been validated externally (a problem since ways of knowing are culturally constructed). In addition, there needs to be cognitive convergence: A process by which individual cognitive structures become more similar or overlapping overtime as people work together. (These teams have to use knowledge to reach their goals.)

To uncover the mechanisms that mediate cognition and performance on a GDT she and other researchers used ethnographic analyses that included: recording spontaneous conversations, coding of their behaviors, team documents, and reports from the team to access convergence or divergence. All of this was in the context of trying to understand whether or not they agreed on the task at hand and could successfully execute that goal.

Here were the obvious findings: GDT's that don't share physically conducive spaces, and unshared contexts across teams create cultural differences in cognition.

Here was the non-intuitive finding: Homogeneous clusters handing work off to other homogeneous clusters did not create cognitive convergence. This happened for two reasons:
Fault lines: Co-occurence of divergence differences in each place created stronger identities that overpowered previous commonalities
Power clusters: Heterogeneous concentration of people in a group with co-located key corporate assets created an exclusionary agenda of believed power.

I hope I captured this fascinating research accurately. Either way, if you are interested in learning more, consider Dr. Baba an expert to turn to.

Suggesting that IBM’s real business opportunity was in empowering the 3B people around the world who don't have internet connectivity was Mohammad Muhsin. He provided some great example of how people were creatively tackling the problem of how individuals can log onto the internet without connectivity?

In one area of Pakistan, people write out their questions on paper which are sent to a nearby community that has access who then on a given day each week the answers are broadcasts via radio.

Another intelligent example was occurring in India where people need to have access to the soil erosion information about their land. In this case, the information about their soil is extremely private information and could easily be used against a farmer in negotiations. To overcome this problem in this village of 6.5 million people (yes, he said village) a public/private partnership was developed to provide information on soil erosion to individuals. But because almost all of these villagers are illiterate, they couldn't even type in their personal information to access the information. The answer: biometric thumbprints scanners are now being used to access private information for illiterates.

Summing it up, he declared, "knowledge empowers the human spirit."

“How many of are you happy?” asked MIT's Tom Malone as he opened his talk about his recent, thought-provoking book, The Future of Work: How the New Order of Business Will Shape Your Organization, Your Management Style and Your Life. While almost everyone raised their hand, he suggested that this is not the norm, and added that "values and happiness" will become be major determinants of where, how, why work is done in the coming decades.

Other great points included:

“We are in the early stages of an increase in human freedom in business, that may be as important to businesses that democracy was for political organizations." He based his assertion on the fact that Low communication costs make it possible to drive change based on human values. Two examples he highlighted this view were the emergence of wikipedia, an open content encyclopedia where anyone can change anything any time and the explosion of Ebay which has over 41 million active buyers/sellers across the globe.

Further exploring his thesis he described how societies have developed over history from bands that were decentralized and unconnected, to kingdoms that were centralized but unconnected in between, to democracies which are relatively decentralized and connected. Building on this he explained how businesses in the 20th Century evolved from small, local businesses (1900) to large centralized corporations (1950) to empowered, outsourced, networked organizations most recently.

Projecting forward he suggested that business organizations where independent decisions are valued will create higher motivation, more creativity, and greater responsiveness. Sounds a bit like the Parecon thesis for business.

From the inside cover of his book: "Imagine organizations in which bosses give employees enormous freedom to decide what to do. Imagine electing your own bosses and voting directly on important company decsions. Imagine organizations in which most workers aren't employees at all, but electronically connected freelancers living wherever they want to. And imagine that all this freedom in business lets people get more of whatever they want in life -- money, interesting work, the chance to help others, or more time with their families."

I had a chance to speak with Tom about our emerging neurosociety and its relevance to his thinking around the future of work, and his response was exactly what I have posited, "This sounds very real, a lot more real than the current hype surrounding nanotechnologies impact on the future of business, politics and culture." It was as if he had read my piece Is It a Nano or a Neuro Wave?

Update: See Dave Pollards post Centralize/Decentralize for some intelligent commentary on Tom's book.

Two talks covered different aspects of the international outsourcing issue.

Discussing the history of US outsourcing to India was Rafique Dosanni who called in from India where he is doing his latest research. In short, he detailed how India would like to climb up the value chain in software development all the way up to ownership of whole product, but cross-cultural issues continue to stem this possibility.

One clear example he used of outsourcing that was sure to occur on a massive scale in the next few years was call centers. 6 million Americans are currently employed at call centers with an average hourly wage of $8. In India, the average hourly wage is $2. When asked if this would hurt the US economy he commented that it definitely will if these workers don't have the opportunity to be retrained for a new line of work. With the average call center worker in the U.S. having 25 years of experience compared to 3 years in India, he suggested that it might be hard for these workers to easily motivate to get retrained.

Exploring the outsourcing of Japan software to India was Geoff Walsham who made the point that even though Chinese software engineers are 1/3 the cost of Japanese programmers and India's are one half the price of a Japanese software engineer, Japan still prefers to outsource to India. The reason, India has a better grasp of the media technologies and better toolsets. However, looking forward he suggested this would change, especially since the primary second language that Chinese programmers are now learning is Japanese. This gives new meaning to what goes around comes around.

Yesterday's Redwood Neuroscience Institute's Stanford Theoretical Neuroscience Lecture featured William Calvin from the University of Washington.

The general theme of his talk was creativity. "How you do something you’ve never done exactly that way before, yet get it right the first time?"

His answer: You can have competitions between categories, between movement programs, between relations, between analogies. That’s what a Darwin Machine in neocortex could buy you: a general process for quality creativity at various levels.

Some of the most interesting work on the neurobiology of creativity is being conducted by Dr. Rosa-Aurora Chavez from the National Institute of Psychiatry in Mexico City. To determine if there was a genetic component to creativity, she took blood samples from 100 recognized artists and scientists. Her findings showed that highly creative individuals had increased expression of specific serotonin transporter and dopamine receptor genes.

She then performed functional neuroimaging experiments on a dozen of these creative minds, concluding that creative individuals had significantly higher activation in the right and left cerebellum, frontal and temporal lobes, while they performed creative tasks.

Creativity research has important implications for business innovation and investment. While standard IQ tests and college entrance exams focus on convergent thinking, i.e. finding the right answer, creative individuals excel at divergent thinking, i.e. discovering multiple potential solutions. The typical behaviors of creative individuals, such as novelty seeking and harm avoidance, as well as, high emotional, sensual and physical over-excitability, often result in the abandonment of projects.

In today’s rushed corporate world focused on quenching the financial markets thirst for efficiency, there is little room for individuals who do not predictably meet deadlines. Further research might validate that sustained financial support of think tanks could produce more innovations. Imagine if the Medici family had not backed Michelangelo, a creative genius who is known to have left over half of his sculptures unfinished.

How many cures for diseases and market opportunities have been missed as a result of short-circuiting the creative process?

The Economist reported last week about a group of researchers who are exploring the neurobiology of religious experiences.

Until recently, religion and spirituality were deemed as 'cultural