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Zack Lynch is author of The Neuro Revolution: How Brain Science Is Changing Our World (St. Martin's Press, July 2009).
He is the founder and executive director of the Neurotechnology Industry Organization (NIO) and co-founder of NeuroInsights. He serves on the advisory boards of the McGovern Institute for Brain Research at MIT, the Center for Neuroeconomic Studies, Science Progress, and SocialText, a social software company. Please send newsworthy items or feedback - to Zack Lynch.
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July 26, 2004

Sarin Gas Neuroprotectant in Development

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Posted by Zack Lynch

Neurowarfare is a very real and growing threat. In an effort to accelerate new drugs and vaccines against potential bioterror weapons including anthrax, smallpox, plague and the Ebola virus, the House of Representatives approved last week a $5.6 billion anti- terrorism initiative called Project Bioshield.

While American's focus on bioweapons, other governments are making headway on new ways to stem deadly the impact of neuroweapons. This week at Singapore International Neuroscience Conference, researchers from DSO National Laboratories presented new findings that showed how epidural clonidine is used with two other drugs it can protect brain cells from being destroyed by nerve agents, like sarin gas. Preliminary tests showed that the combination reduces brain damage significantly and does not cause breathing complications, thus increasing survival rates, compared to the cocktail now used in situations like the 1995 sarin gas attack in Tokyo subways by members of Japanese cult Aum Shinrikyo.

As the Strait Times reports, "While the new combination has been shown to protect most of an affected person's brain cells even when administered as much as 40 minutes after he is poisoned by biochemicals...the potential downside is that it could lead to psychosis, a mental disorder where the person loses touch with reality, and lead to his being on medication for life." Given these complications, the researchers stated that it will take at least another six to eight years of testing to determine if the new combination should replace the existing one.

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